Teacher Details
Amit Roy
Department of Biotechnology
amitathens@gmail.com
| 1) | Mazire, P., Chaudhary, D., Thomas, K., Roy, A. (2026). Flavonoids: Novel topoisomerase inhibitors in cancer therapy. Biochimica et Biophysica Acta (BBA)-General Subjects,
1870 (6), 130932.
ISSN(print/online): 0304-4165/1872-8006,
URL/DOI: http://dx.doi.org/10.1016/j.bbagen.2026.130932
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| 2) | Mazire, P., Roy, A. (2026). Lopinavir targets Leishmania topoisomerase I and its combination with Ritonavir exhibits enhanced antileishmanial efficacy in clinical isolates of Leishmania donovani. Acta Tropica,
278, 108082.
ISSN(print/online): 0001-706X/1873-6254,
URL/DOI: http://dx.doi.org/10.1016/j.actatropica.2026.108082
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| 3) | Lamba, S., Mazire, P., Roy, A. (2025). Unveiling the mechanism of hesperidin-induced LdTopI-mediated cell death pathway in protozoan parasite Leishmania donovani. Biochimie,
228, 15-31.
ISSN(print/online): 0300-9084/1638-6183,
URL/DOI: http://dx.doi.org/10.1016/j.biochi.2024.08.008
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| 4) | Mazire, P.H., Shingade, S., Roy, A. (2025). Ritonavir enhances the efficacy of amprenavir: A promising combination therapy by targeting Leishmania DNA topoisomerase I for treatment of visceral leishmaniasis. Experimental Parasitology,
269, 108898.
ISSN(print/online): 0014-4894/1090-2449,
URL/DOI: http://dx.doi.org/10.1016/j.exppara.2025.108898
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| 5) | Das, S., Babu, N.K., Mazire, P., Roy, A., Kumar, R., Singh, S., Sharma, D.K. (2025). Indolylmaleimide derivatives as a new class of anti-leishmanial agents: synthesis and biological evaluation. RSC Medicinal Chemistry,
16 (6), 2808-2818.
ISSN(print/online): 2632-8682,
URL/DOI: http://dx.doi.org/10.1039/d5md00132c
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| 6) | Roy, A. (2025). Urea Stibamine to Modern Chemotherapeutics Against Kala-Azar: The Legacy of Upendranath Brahmachari and the On-going Journey of Drug Development. Academic Journal of Hooghly Mohsin College,
12 (1 & 2), 23-28.
ISSN(print/online): 0973-6212,
URL/DOI: https://hooghlymohsincollege.ac.in/pdf-documents/AJHMC%20june%202025.pdf#page=25
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| 7) | Roy, A., Bera, S., Nath, S., Pakhira, M.C., Sarkar, U. (2025). Effect of Seasonal Variations and Breed Differences on Physiological and Behavioural Parameters of Ghungroo and Large White Yorkshire (LWY) Piglets in Sundarban,West Bengal, India. Journal of Advances in Biology & Biotechnology,
28 (6), 284-297.
ISSN(print/online): 2394-1081,
URL/DOI: https://doi.org/10.9734/jabb/2025/v28i62394
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| 8) | Lamba, S., Roy, A. (2023). Demystifying the potential of inhibitors targeting DNA topoisomerases in unicellular protozoan parasites. Drug Discovery Today,
28 (6), 103574.
ISSN(print/online): 1359-6446/1878-5832,
URL/DOI: http://dx.doi.org/10.1016/j.drudis.2023.103574
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| 9) | Lodha, K., Wavhal, D., Bhujbal, N., Mazire, P., Bhujbal, S., Korde, A., Bagul, K., Roy, A., Meshram, R., Shinde, V. (2023). Synthesis and biological evaluation of 9-aryl-1,8-dioxo-octahydroxanthene derivatives as antileishmanial agents. Results in Chemistry,
5, 100943.
ISSN(print/online): 2211-7156,
URL/DOI: http://dx.doi.org/10.1016/j.rechem.2023.100943
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| 10) | Mazire, P.H., Roy, A. (2023). An integrative in silico and in vitro study identifies Leishmania donovani MAP kinase12 as a probable virulence factor. International Immunopharmacology,
121, 110496.
ISSN(print/online): 1567-5769/1878-1705,
URL/DOI: http://dx.doi.org/10.1016/j.intimp.2023.110496
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| 11) | Kour, P., Saha, P., Bhattacharya, S., Kumari, D., Debnath, A., Roy, A., Sharma, D.K., Mukherjee, D., Singh, K. (2023). Design, synthesis, and biological evaluation of 3,3′-diindolylmethane N-linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity. RSC Medicinal Chemistry,
14 (10), 2100-2114.
ISSN(print/online): 2632-8682,
URL/DOI: http://dx.doi.org/10.1039/D3MD00214D
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| 12) | Mazire, P.H., Saha, B., Roy, A (2022). Immunotherapy for visceral leishmaniasis: A trapeze of balancing counteractive forces. International Immunopharmacology,
110, 108969.
ISSN(print/online): 1567-5769/1878-1705,
URL/DOI: http://dx.doi.org/10.1016/j.intimp.2022.108969
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| 13) | Mazire, P., Agarwal, V., Roy, A. (2022). Road-map of pre-clinical treatment for Visceral Leishmaniasis. Drug Development Research,
83 (2), 317-327. Google Scholar Citations,
ISSN(print/online): 0272-4391/1098-2299,
URL/DOI: http://dx.doi.org/10.1002/ddr.21907
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| 14) | Medha, M., Roy, A. (2022). Microgravity: New aspect for breast cancer treatment, a review. Acta Astronautica,
190, 62-73.
ISSN(print/online): 0094-5765,
URL/DOI: http://dx.doi.org/10.1016/j.actaastro.2021.09.045
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| 15) | Lamba, S., Roy, A. (2022). DNA topoisomerases in the unicellular protozoan parasites: Unwinding the mystery. Biochemical Pharmacology,
203, 115158.
ISSN(print/online): 0006-2952/1873-2968,
URL/DOI: http://dx.doi.org/10.1016/j.bcp.2022.115158
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| 16) | Roy, A. (2022). DNA Topoisomerase as drug target in unicellular protozoan parasite Leishmania donovani. Indian Journal of Physiology and Allied Sciences,
74 (2), 28-35.
ISSN(print/online): 0367-8350,
URL/DOI: http://dx.doi.org/10.55184/ijpas.v74i02.55
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| 17) | Roy, A., Behera, S., Mazire, P.H., Kumari, B., Mandal, A., Purkait, B., Ghosh, P., Das, P., Das, P. (2021). The HIV − 1 protease inhibitor Amprenavir targets Leishmania donovani topoisomerase I and induces oxidative stress-mediated programmed cell death. Parasitology International,
82, 102287 . Google Scholar Citations,
ISSN(print/online): 1383-5769/1873-0329,
URL/DOI: http://dx.doi.org/10.1016/j.parint.2021.102287
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| 18) | Kjeldsen, E., Nielsen, C.J., Roy, A., Tesauro, C., Jakobsen, A.K., Stougaard, M., Knudsen, B.R. (2018). Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5. Cancer Genomics and Proteomics,
15 (0), 91-114. Google Scholar Citations,
ISSN(print/online): 1109-6535/1790-6245,
URL/DOI: http://dx.doi.org/10.21873/cgp.20068
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| 19) | Singh, M.K., Bhaumik, S.K., Karmakar, S., Paul, J., Sawoo, S., Majumder, H.K., Roy, A. (2017). Copper salisylaldoxime (CuSAL) imparts protective efficacy against visceral leishmaniasis by targeting Leishmania donovani topoisomerase IB. Experimental Parasitology,
175 (0), 8-20. Google Scholar Citations,
ISSN(print/online): 0014-4894/1090-2449,
URL/DOI: http://dx.doi.org/10.1016/j.exppara.2017.02.010
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| 20) | Jensen, N.F., Agama, K., Roy, A., Smith, D.H., Pfister, T.D., Rømer, M.U., Zhang, H.L., Doroshow, J.H., Knudsen, B.R., Stenvang, J., Brunner, N. (2016). Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations. Journal of Experimental and Clinical Cancer Research,
35 (1), 56. Google Scholar Citations,
ISSN(print/online): 1756-9966,
URL/DOI: http://dx.doi.org/10.1186/s13046-016-0335-x
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| 21) | Roy, A., Tesauro, C., Frøhlich, R., Hede, M.S., Nielsen, M.J., Kjeldsen, E., Bonven, B., Stougaard, M., Gromova, I., Knudsen, B.R. (2014). Decreased Camptothecin Sensitivity of the Stem-Cell-like Fraction of Caco2 cells Correlates with an Altered Phosphorylation Pattern of Topoisomerase I. PloS One,
9 (6), e99628. Google Scholar Citations,
ISSN(print/online): 1932-6203,
URL/DOI: http://dx.doi.org/10.1371/journal.pone.0099628
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| 22) | Proszek, J., Roy, A., Jakobsen, A.K., Frøhlich, R., Knudsen, B.R., Stougaard, M. (2014). Topoisomerase I as a biomarker: Detection of activity at the single molecule level. Sensors,
14 (1), 1195-1207. Google Scholar Citations,
ISSN(print/online): 1424-3210/1424-8220,
URL/DOI: http://dx.doi.org/10.3390/s140101195
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| 23) | Juul, S., Nielsen, C.J., Labouriau, R., Roy, A., Tesauro, C., Jensen, P.W., Harmsen, C., Kristoffersen, E.L., Chiu, Y.L., Frøhlich, R., Fiorani, P. (2012). A Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria Causing Plasmodium Parasites Based on Enzyme Activity Measurement. ACS Nano,
6 (12), 10676-10683. Google Scholar Citations,
ISSN(print/online): 1936-0851/1936-086X,
URL/DOI: http://dx.doi.org/10.1021/nn3038594
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| 24) | Sengupta, S., Ganguly, A., Roy, A., BoseDasgupta, S., D’Annessa, I., Desideri, A., Majumder, H.K. (2011). ATP independent type IB topoisomerase of Leishmania donovani is stimulated by ATP: an insight into the functional mechanism. Nucleic Acids Research,
39 (8), 3295-3309. Google Scholar Citations,
ISSN(print/online): 0305-1048/1362-4962,
URL/DOI: http://dx.doi.org/10.1093/nar/gkq1284
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| 25) | Roy, A., Chowdhury, S., Sengupta, S., Mandal, M., Jaisankar, P., D'Annessa, I., Desideri, A., Majumder, H.K. (2011). Development of Derivatives of 3, 3′-Diindolylmethane as Potent Leishmania donovani Bi-Subunit Topoisomerase IB Poisons. PloS One,
6 (12), e28493. Google Scholar Citations,
ISSN(print/online): 1932-6203,
URL/DOI: http://dx.doi.org/10.1371/journal.pone.0028493
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| 26) | Roy, A., D'Annessa, I., Nielsen, C.J., Tordrup, D., Laursen, R.R., Knudsen, B.R., Desideri, A., Andersen, F.F. (2011). Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum. Molecular Biology International,
2011 (0), 854626. Google Scholar Citations,
ISSN(print/online): 2090-2190,
URL/DOI: http://dx.doi.org/10.4061/2011/854626
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Publications Before 2011 |
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| 27) | Banerjee, B., Roy, A., Sen, N., Majumder, H.K. (2010). A tyrosyl DNA phosphodiesterase 1 from kinetoplastid parasite Leishmania donovani (LdTdp1) capable of removing topo I-DNA covalent complexes. Molecular Microbiology,
78 (1), 119-137. Google Scholar Citations,
ISSN(print/online): 0950-382X/1365-2958,
URL/DOI: http://dx.doi.org/10.1111/j.1365-2958.2010.07318.x
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| 28) | Roy, A., BoseDasgupta, S., Ganguly, A., Jaisankar, P., Majumder, H.K. (2009). Topoisomerase I Gene Mutations at F270 in the Large Subunit and N184 in the Small Subunit Contribute to the Resistance Mechanism of the Unicellular Parasite Leishmania donovani towards 3,3′-Diindolylmethane. Antimicrobial Agents and Chemotherapy,
53 (6), 2589-2598. Google Scholar Citations,
ISSN(print/online): 0066-4804/1098-6596,
URL/DOI: http://dx.doi.org/10.1128/aac.01648-08
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| 29) | Ganguly, A., Sengupta, S., BoseDasgupta, S., Roy, A., Majumder, H.K. (2009). Mutational studies reveal lysine 352 on the large subunit is indispensable for catalytic activity of bi-subunit topoisomerase I from Leishmania donovani. Molecular and Biochemical Parasitology,
165 (1), 57-66. Google Scholar Citations,
ISSN(print/online): 0166-6851/1872-9428,
URL/DOI: http://dx.doi.org/10.1016/j.molbiopara.2009.01.002
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| 30) | BoseDasgupta, S., Ganguly, A., Das, B.B., Roy, A., Khalkho, N.V., Majumder, H.K. (2008). The large subunit of Leishmania topoisomerase I functions as the ‘molecular steer’ in type IB topoisomerase. Molecular Microbiology,
67 (1), 31-46. Google Scholar Citations,
ISSN(print/online): 0950-382X/1365-2958,
URL/DOI: http://dx.doi.org/10.1111/j.1365-2958.2007.06002.x
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| 31) | BoseDasgupta, S., Ganguly, A., Roy, A., Mukherjee, T., Majumder, H.K. (2008). A novel ATP-binding cassette transporter, ABCG6 is involved in chemoresistance of Leishmania. Molecular and Biochemical Parasitology,
158 (2), 176-188. Google Scholar Citations,
ISSN(print/online): 0166-6851/1872-9428,
URL/DOI: http://dx.doi.org/10.1016/j.molbiopara.2007.12.007
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| 32) | Bosedasgupta, S., Das, B.B., Sengupta, S., Ganguly, A., Roy, A., Tripathi, G., Majumder, H.K. (2008). Amino acids 39–456 of the large subunit and 210–262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania. Biochemical Journal,
409 (2), 481-489. Google Scholar Citations,
ISSN(print/online): 0264-6021/1470-8728,
URL/DOI: http://dx.doi.org/10.1042/BJ20071358
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| 33) | Das, R., Roy, A., Dutta, N., Majumder, H.K., (2008). Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani. Apoptosis,
13 (7), 867-882. Google Scholar Citations,
ISSN(print/online): 1360-8185/1573-675X,
URL/DOI: http://dx.doi.org/10.1007/s10495-008-0224-7
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| 34) | BoseDasgupta, S., Das, B.B., Sengupta, S., Ganguly, A., Roy, A., Dey, S., Tripathi, G., Dinda, B., Majumder, H.K. (2008). The caspase-independent algorithm of programmed cell death in Leishmania induced by baicalein: the role of LdEndoG, LdFEN-1 and LdTatD as a DNA ‘degradesome’. Cell Death and Differentiation,
15 (10), 1629-40. Google Scholar Citations,
ISSN(print/online): 1350-9047/1476-5403,
URL/DOI: http://dx.doi.org/10.1038/cdd.2008.85
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| 35) | Pramanick, S., Roy, A., Ghosh, S., Majumder, H.K., Mukhopadhyay, S. (2008). Withanolide Z, a New Chlorinated Withanolide from Withania somnifera. Planta Medica,
74 (14), 1745-1748. Google Scholar Citations,
ISSN(print/online): 0032-0943/1439-0221,
URL/DOI: http://dx.doi.org/10.1055/s-2008-1081357
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| 36) | Roy, A., Das, B.B., Ganguly, A., Bose Dasgupta, S., Khalkho, N.V., Pal, C., Dey, S., Giri, V.S., Jaisankar, P., Dey, S., Majumder, H.K. (2008). An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3'-diindolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to enzyme. Biochemical Journal,
409 (2), 611-622. Google Scholar Citations,
ISSN(print/online): 0264-6021/1470-8728,
URL/DOI: http://dx.doi.org/10.1042/BJ20071286
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| 37) | Roy, A., Ganguly, A., BoseDasgupta, S., Das, B.B., Pal, C., Jaisankar, P., Majumder, H.K. (2008). Mitochondria-Dependent Reactive Oxygen Species-Mediated Programmed Cell Death Induced by 3,3′-Diindolylmethane through Inhibition of F0F1-ATP Synthase in Unicellular Protozoan Parasite Leishmania donovani. Molecular Pharmacology,
74 (5), 1292-1307.
ISSN(print/online): 0026-895X/1521-0111,
URL/DOI: http://dx.doi.org/10.1124/mol.108.050161
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| 38) | Das, B.B., Bose Dasgupta, S., Ganguly, A., Mazumder, S., Roy, A., Majumder, H.K. (2007). Leishmania donovanibisubunit topoisomerase I genefusion leads to an active enzyme with conserved type IBenzyme function. FEBS Journal,
274 (1), 150-163. Google Scholar Citations,
ISSN(print/online): 1742-464X/1742-4658,
URL/DOI: http://dx.doi.org/10.1111/j.1742-4658.2006.05572.x
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| 39) | Ganguly, A., Das, B., Roy, A., Sen, N., Dasgupta, S.B., Mukhopadhayay, S., Majumder, H.K. (2007). Betulinic Acid, a Catalytic Inhibitor of Topoisomerase I, Inhibits Reactive Oxygen Species–Mediated Apoptotic Topoisomerase I–DNA Cleavable Complex Formation in Prostate Cancer Cells but Does Not Affect the Process of Cell Death. Cancer Research,
67 (24), 11848-11858. Google Scholar Citations,
ISSN(print/online): 0008-5472/1538-7445,
URL/DOI: http://dx.doi.org/10.1158/0008-5472.CAN-07-1615
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| 40) | Das, B.B., Sen, N., Roy, A., Dasgupta, S.B., Ganguly, A., Mohanta, B.C., Dinda, B., Majumder, H.K. (2006). Differential induction of Leishmania donovani bi-subunit topoisomerase I–DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I. Nucleic Acids Research,
34 (4), 1121-1132. Google Scholar Citations,
ISSN(print/online): 0305-1048/1362-4962,
URL/DOI: http://dx.doi.org/10.1093/nar/gkj502
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| 41) | Ganguly, A., Das, B.B., Sen, N., Roy, A., Dasgupta, S.B., Majumder, H.K. (2006). ‘LeishMan’ topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani. Nucleic Acids Research,
34 (21), 6286-6297. Google Scholar Citations,
ISSN(print/online): 0305-1048/1362-4962,
URL/DOI: http://dx.doi.org/10.1093/nar/gkl829
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